EdenteV2, France, Analysis, bibRecord, 000350

The effects of residual Pain on oxygenation and breathing pattern during morphine analgesia

Identifieur interne : 000350 ( France/Analysis ); précédent : 000349; suivant : 000351

The effects of residual Pain on oxygenation and breathing pattern during morphine analgesia

Auteurs : X. Combes [France] ; C. Cerf [France] ; D. Bouleau [France] ; P. Duvaldestin [France] ; G. Dhonneur [France]

Source :

Anesthesia and analgesia [ 0003-2999 ] ; 2000.

RBID : Pascal:00-0062823

Descripteurs français

Pascal (Inist)
- Douleur, Postopératoire, Morphine, Analgésique narcotique, Voie intraveineuse, Chimiothérapie, Traitement, Homme, Autoadministration, Dépression respiratoire, Toxicité, Anesthésie régionale, Analgésie, Opiacés.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Analgesia, Chemotherapy, Human, Intravenous administration, Morphine, Narcotic analgesic, Opiates, Pain, Postoperative, Regional anesthesia, Respiratory depression, Self administration, Toxicity, Treatment.

Abstract

To determine the influence of pain on opioid-induced respiratory depression, we studied oxygenation and breathing patterns in 40 patients scheduled for knee surgery during postoperative patient-controlled analgesia (PCA). After 1 h of morphine PCA, patients were randomized to receive either 20 mL of placebo or bupivacaine 0.25% through a crural nerve catheter and allowed to use PCA for one more hour. Abnormal breathing events were identified and characterized by using the Edentrace II device (Nellcor, Jouy-en-Josas, France). The Spo₂ below which the patient spent 25% and 50% of a studied period was calculated (Spo₂₂₅, Spo₂₅₀). Pain relief with regional analgesia increased the incidence of abnormal respiratory events associated with oxygen desaturation: during the second period, the pain score was lower in the bupivacaine group (0.7 ± 1 vs 4.1 ± 1.2), morphine consumption was larger in the placebo group (4.2 ± 1.3 vs 0.7 ± 1.4 mg), and there were more abnormal obstructive breathing events in the bupivacaine group (11 ± 16 vs 3.7 ± 4.3). Spo₂₂₅. and Spo₂₅₀. were lower in the bupivacaine than in placebo group (91.5% ± 2.8% vs 93.1% ± 2.1%, 92.9% ± 2.4% vs 94.2% ± 1.8%). Implications: Pain relief with regional analgesia in patients previously treated with opioids increases the incidence of abnormal respiratory events associated with oxygen desaturation.

Affiliations:

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Pascal:00-0062823

Le document en format XML

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<term>Pain</term>
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<term>Analgésique narcotique</term>
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<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Homme</term>
<term>Autoadministration</term>
<term>Dépression respiratoire</term>
<term>Toxicité</term>
<term>Anesthésie régionale</term>
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<front><div type="abstract" xml:lang="en">To determine the influence of pain on opioid-induced respiratory depression, we studied oxygenation and breathing patterns in 40 patients scheduled for knee surgery during postoperative patient-controlled analgesia (PCA). After 1 h of morphine PCA, patients were randomized to receive either 20 mL of placebo or bupivacaine 0.25% through a crural nerve catheter and allowed to use PCA for one more hour. Abnormal breathing events were identified and characterized by using the Edentrace II device (Nellcor, Jouy-en-Josas, France). The Spo<sub>2</sub>
 below which the patient spent 25% and 50% of a studied period was calculated (Spo<sub>225</sub>
, Spo<sub>250</sub>
). Pain relief with regional analgesia increased the incidence of abnormal respiratory events associated with oxygen desaturation: during the second period, the pain score was lower in the bupivacaine group (0.7 ± 1 vs 4.1 ± 1.2), morphine consumption was larger in the placebo group (4.2 ± 1.3 vs 0.7 ± 1.4 mg), and there were more abnormal obstructive breathing events in the bupivacaine group (11 ± 16 vs 3.7 ± 4.3). Spo<sub>225</sub>
. and Spo<sub>250</sub>
. were lower in the bupivacaine than in placebo group (91.5% ± 2.8% vs 93.1% ± 2.1%, 92.9% ± 2.4% vs 94.2% ± 1.8%). Implications: Pain relief with regional analgesia in patients previously treated with opioids increases the incidence of abnormal respiratory events associated with oxygen desaturation.</div>
</front>
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The effects of residual Pain on oxygenation and breathing pattern during morphine analgesia

The effects of residual Pain on oxygenation and breathing pattern during morphine analgesia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

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